修饰抗体 Products
赖氨酸双甘氨酸抗体偶联树脂
杭州景杰生物科技有限公司
Anti-diglycine lysine antibody conjugated agarose beads

Cat#:

PTM-1104

Ab Type:

P

Applications:

IAC IP

Species:

All

Price: (0.5 ml)

22432.00

Price: (0.1 ml)

 7800.00


Product Description

The rabbit-derived polyclonal anti-diglycine lysine antibodies (anti-K-?-G-G antibody) are crosslinked to agarose with stable amide linkages. In the global proteomic screening of lysine ubiquitination, the product was well utilized as affinity matrix to specifically capture the peptides bearing lysine-?-G-G residues in all species.


Source/Purification

/

Specificity

/

Recommended Applications

Peptide immunoprecipitation for lysine-?-G-G proteomics; Immuno-affinity chromatography.


Recommended antibody dilution

/

Important

/

Scientific Description

Ubiquitin(Ub) is a highly conserved protein of 8 kDa that covalently attaches to lysine residues of target proteins. This occurs through a three-step process involving Ub-activating (E1), Ub-conjugating (E2) and Ub-ligating (E3) enzymes. Ubiquitin-dependent processes are commonly modulated via formation of polyubiquitin chains, whereby the C terminus of a chain extending ubiquitin becomes linked to the N terminus or one of seven lysine residues (Lys-6,Lys-11, Lys-27, Lys-29, Lys-33, Lys-48, and Lys-63) within a substrate-bound ubiquitin molecule. The modification of lysine ubiquitin (ubiquitination) plays a central role in the regulation ofmultiple cellular processes. In addition to targeting proteins for proteasomal degradation, ubiquitination modulates membrane protein trafficking, alters protein-protein interactions, and controls the activity of many signal transduction pathways. A large family of enzymes involved in ubiquitin conjugation controls these diverse functions.


Storage & Stability

Store product at -20oC. Avoid repeated freeze/thaw. Antibody is supplied in PBS with 50% glycerol and 0.01% sodium azide.Stable for 12 months from date of receipt.


**Research purposes only. Not intended to be used for therapeutic or diagnostic purposes in humans or animals.



Song Y,et al.Quantitative global proteome and lysine succinylome analyses provide insights into metabolic regulation and lymph node metastasis in gastric cancer.Sci Rep. 2017 Feb 6;7:42053. doi: 10.1038/srep42053.



Peptide immunoprecipitation for lysine-?-G-G proteomics; Immuno-affinity chromatography.

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