修饰抗体 Products
赖氨酸丁酰化抗体偶联树脂
杭州景杰生物科技有限公司
Anti-butyryllysine antibody beaded agarose

Cat#:PTM-302Ab Type:P

Ab Size:0.5 mLApplications:IAC

Species:AllPrice:¥ 22432.00



Product Description

The rabbit-derived polyclonal anti-butyryllysine antibodies are crosslinked to agarose with stable amide linkages. In the global proteomic screening of lysine butyrylation, the product was well utilized as affinity matrix to specifically capture the peptides/proteins bearing butyryllysine residues in all species.


Source/Purification

/

Specificity

All

Recommended Applications

Protein/peptide immunoprecipitation for lysine butyrylation proteomics; Immuno-affinity chromatography.
 

Recommended antibody dilution

/

Important

/

Scientific Description

Butyrylation of lysine, structurally similar to lysine acetylation and lysine propionylation, is a newly identified reversible modification controlling protein activity. With integrated proteomic approaches and biochemistry analysis, lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes in wide ranges of proteins including histones and non-histone substrates. Given the facts that many lysine residues in histones and non-histone substrates, such as p53, p300/CBP, are butyrylated, lysine butyrylation may play a vital role in epigenetic modulation by impacting chromatin dynamics and plasticity, DNA transcriptional regulation and tumorigenesis, etc


Storage & Stability

Store product at -20oC. Avoid repeated freeze/thaw. Antibody is supplied in PBS with 50% glycerol and 0.01% sodium azide.Stable for 12 months from date of receipt.


**Research purposes only. Not intended to be used for therapeutic or diagnostic purposes in humans or animals.



Xu G,et al.SAHA regulates histone acetylation, Butyrylation, and protein expression in neuroblastoma.J Proteome Res. 2014 Oct 3;13(10):4211-9. doi: 10.1021/pr500497e. Epub 2014 Sep 22.

Protein/peptide immunoprecipitation for lysine butyrylation proteomics; Immuno-affinity chromatography.

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