修饰抗体 Products
赖氨酸2-羟基异丁基酰化抗体偶联树脂
杭州景杰生物科技有限公司
Anti-2-hydroxyisobutyryllysine antibody conjugated agarose beads

Cat#:

PTM-804

Ab Type:

P/M

Applications:

IAC IP

Species:

All

Price: (0.5 ml)

22432.00

Price: (0.1 ml)

 7800.00


Product Description

A mixture of high quality rabbit-derived anti-2-hydroxyisobutyryllysine polyclonal antibodies are cross-linked to beaded agarose with stable amide linkages. With the combined advantages of polyclonal and monoclonal antibodies in global proteomic screening of 2-hydroxyisobutyryllysine, this product presents extra ordinary capability to specifically capture the peptides/proteins bearing lysine 2-hydroxyisobutyrylated residues.


Source/Purification

/


Specificity

All

Recommended Applications

Protein/peptide immunoprecipitation for lysine 2-hydroxyisobutyrylation proteomics; Immuno-affinity chromatography.


Recommended antibody dilution

/

Important

/

Scientific Description

Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, ubiquitylation, etc.  2-hydroxyisobutyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine 2-hydroxyisobutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine 2-hydroxyisobutyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation.


Storage & Stability

Protein/peptide immunoprecipitation for lysine 2-hydroxyisobutyrylation proteomics; Immuno-affinity chromatography.


**Research purposes only. Not intended to be used for therapeutic or diagnostic purposes in humans or animals.  


1. Lunzhi D.,etal.(2014). NAT. CHEM. BIOL. Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

Protein/peptide immunoprecipitation for lysine 2-hydroxyisobutyrylation proteomics; Immuno-affinity chromatography.

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