修饰抗体 Products
赖氨酸戊二酰化抗体偶联树脂
杭州景杰生物科技有限公司
Anti-glutaryllysine antibody conjugated agarose beads

Cat#:

PTM-1154

Ab Type:

P

Applications:

IAC IP

Species:

All

Price: (0.5 ml)

22432.00

Price: (0.1 ml)

 7800.00


Product Description

The rabbit-derived polyclonal anti-glutaryllysine antibodies are crosslinked to agarose with stable amide linkages. In the global proteomic screening of lysine glutarylation, the product was well utilized as affinity matrix to specifically capture the peptides/proteins bearing glutaryllysine residues in all species.


Source/Purification

/


Specificity

All

Recommended Applications

Protein/peptide immunoprecipitation for lysine glutarylation proteomics; Immuno-affinity chromatography.


Recommended antibody dilution

/

Important

/

Scientific Description

Lysine glutarylation is a newly-identified histone post-translational modification by integrated proteomic approaches and elaborate biochemistry analyses. It has been shown that lysine glutarylation is an evolutionarily conserved PTM in multiple species of both prokaryotes and eukaryotes in a wide range of proteins, both in histones and non-histone substrates. Lysine glutarylation is a SIRT5- and nutrient-regulated PTM, which impacts metabolic processes and other mitochondrial functions.


Storage & Stability

Store product at -20oC. Avoid repeated freeze/thaw. Antibody is supplied in PBS with 50% glycerol and 0.01% sodium azide.Stable for 12 months from date of receipt.


**Research purposes only. Not intended to be used for therapeutic or diagnostic purposes in humans or animals.


1. Tan, M.J. et al (2014) Cell Metab. 19, 605.

2. Xie L,et al.Proteome-wide Lysine Glutarylation Profiling of the Mycobacterium tuberculosis H37Rv. J Proteome Res. 2016 Apr 1;15(4):1379-85. doi: 10.1021/acs.jproteome.5b00917. Epub 2016 Feb 25.


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