修饰抗体 Products
赖氨酸β-羟基丁酰化抗体偶联树
杭州景杰生物科技有限公司
Anti-β-hydroxybutyryllysine antibody conjugated agarose beads

Cat#:

PTM-1204

Ab Type:

P/M

Applications:

IAC IP

Species:

All

Price: (0.5 ml)

22432.00

Price: (0.1 ml)

 7800.00


Product Description

A mixture of high quality rabbit-derived anti-β-hydroxybutyryllysine polyclonal antibodies and mouse-derived anti-β-hydroxybutyryllysine monoclonal antibodies are cross-linked to beaded agarose with stable amide linkages. With the combined advantages of polyclonal and monoclonal antibodies in global proteomic screening of β-hydroxybutyryllysine, this product presents extra ordinary capability to specifically capture the peptides/proteins bearing lysine β-hydroxybutyryllysine residues. 


Source/Purification

/


Specificity

All

Recommended Applications

Protein/peptide immunoprecipitation for lysine β-hydroxybutyryllysine proteomics; Immuno-affinity chromatography (IAP).


Recommended antibody dilution

/

Important

/

Scientific Description

Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, ubiquitylation, etc. β-hydroxybutyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine β-hydroxybutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine β-hydroxybutyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation

 

Storage & Stability

Store at -20℃ and avoid freeze. Stable for 12 months from date of receipt.



Zhongyu X, Di Z., etal.(2016). Mol. cell. 62, 194-206.  Metabolic regulation of gene expression by histone lysine

Protein/peptide immunoprecipitation for lysine β-hydroxybutyryllysine proteomics; Immuno-affinity chromatography (IAP).



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